Pilot Scale Fermenters for Biotech Scale-Up & Process Development

BioGene Pilot Scale Fermenters are advanced bioreactors engineered to bridge laboratory research and industrial production. As a manufacturer, supplier, and exporter in India and worldwide, Biotechnologies Inc. delivers cutting?edge solutions for process development, strain optimization, enzyme production, and pre?commercial biotech applications.

Crafted with SS316L grade vessels, integrated SIP/CIP systems, and intelligent PLC/HMI control panels, BioGene fermenters ensure real?time monitoring, precise parameter control, and complete data logging.

Trusted by leading biotech companies, research institutions, and pharmaceutical industries, these systems provide reliable scale?up solutions that transform lab innovation into industrial manufacturing. Designed in India and globally validated, BioGene fermenters embody quality, efficiency, and innovation.

Applications

• Scale-up studies from lab to industrial production
• Microbial fermentation for enzymes, vaccines, and biopharmaceuticals
• Biofertilizer and agricultural microbial inoculant production
• Pilot plant trials for new product development
• Fermentation optimization for biotech start-ups and research institutes
• Export-ready systems for international biotech facilities

BioGene pilot scale fermenters recognised as quality product at world over where in pilot matches are to be fermented for large scale industrial bioprocess products this pilot fermenters from buyers in our in applications for cultivation test whether this mammalian cells have to be cultivated or sugar, carbohydrates are to be broken to generate alcohol,Lipase,invertase enzymes through genetically modified microbes.

BioGene Pilot Scale Fermenters Bioreactors comes in single vessel or multiple vessels of similar or different capacities which can be easily controlled through micro processor situated at a remote place. 

Wi-Fi or online driven menus with controls through the colour monitors enabling the user to Check the process values and monitor programs,control and visualise the flowchart of the present online process.

BioGene Pilot Scale Fermenters Are a true solution to pilot fermentation needs.

 

 

 

Feature

Safety Features and Options

• Capacities from 50L to 200L
• Automatic temperature, pH, DO, and agitation control
• High-efficiency aeration & mixing for uniform growth conditions
• GMP-compliant design with sanitary-grade construction
• Modular, scalable, and customizable configurations
• Easy-to-clean CIP/SIP systems for sterile operation

Control

Enhanced Communications & Control Options

• PLC/SCADA-based automation with recipe management
• HMI touchscreen with multi-language support
• Real-time process monitoring & data logging
• Remote operation & troubleshooting capability
• Integrated alarms and safety interlocks

Construction

  • SS316L contact parts, polished to Ra ≤ 0.6 µm
  • SS304 external body for durability
  • Heavy-duty frame with vibration damping
  • Sanitary piping & valves with tri-clamp connections
  • High-grade seals and gaskets for sterile operation
Parameter Specification
Capacity Range 10L – 500L (custom options available)
Vessel Material SS 316L with mirror polish
Agitation System Mechanical seal stirrer with variable speed
Aeration System Ring sparger with sterile filter
Control System PLC/SCADA based with touchscreen HMI
Sensors pH, DO, Temperature, Foam, Level
Sterilization SIP (Steam-in-Place) & CIP (Clean-in-Place)
Compliance ISO, CE, GMP certified
Power Supply 230V / 415V AC, 50Hz (custom options)

A pilot scale fermenter is a mid-sized bioreactor, typically ranging from 10 to 300 liters, used to bridge the gap between small lab-scale experiments and full commercial production. You would need one when you have already validated your process at the bench scale and want to confirm that your fermentation parameters, yields, and product quality remain consistent before committing to large scale manufacturing. It helps identify scale up challenges early, such as changes in mixing, oxygen transfer, or heat removal that do not show up in smaller vessels.

Our pilot scale fermenters allow real time monitoring and control of temperature, pH, dissolved oxygen, agitation speed, and pressure, along with feed rates for nutrients or pH adjusting agents. Most systems also support foam control, gas flow regulation, and sampling ports for offline analysis. This level of control ensures your process runs under conditions that closely mimic what you plan to use at production scale, giving you reliable data for scale up decisions.

Yes, pilot scale fermenters are generally versatile enough to handle bacterial, yeast, fungal, mammalian cell, and even some algal cultures, provided the appropriate vessel configuration and accessories are used. Depending on your application, you may need specific impeller designs, sparger types, or single use versus stainless steel vessels. Our team can help you select the right configuration based on your organism, required oxygen transfer rate, and shear sensitivity.

Scaling up is much smoother when the pilot fermenter is designed with geometric and process similarity to your intended production scale equipment. This means matching vessel aspect ratios, impeller types, and control strategies as closely as possible. While some adjustments are always needed due to changes in mixing time, mass transfer, and heat exchange at larger volumes, using a well designed pilot system significantly reduces the number of surprises and speeds up technology transfer.

We provide installation qualification, operational qualification, and performance qualification support to ensure your fermenter is validated and ready for regulated environments if needed. Ongoing services include calibration of sensors, preventive maintenance visits, software updates for the control system, and technical troubleshooting support. Training for your operators is also available, covering both routine operation and basic troubleshooting so your team can run the system confidently with minimal downtime.
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